Note: The Organix test has been updated. See new sample test report and guide under 'Other Info' Indications Organix is effective for patient concerns such as: - Mood Disorders
- Mitochondrial Dysfunction
- Fatigue
- Chronic Stress
- Inflammation
The Organix report categorizes test results into major metabolic areas: - Malabsorption and Dysbiosis Markers
- Cellular Energy & Mitochondrial Markers
- Vitamin Markers
- Neurotransmitter Metabolites
- Toxin & Detoxification Markers
- Oxalate Markers
Coming soon
Practical
Specimen requirements: FMV urine, Full vial frozen
Agre requirements: Suitable for children over 2 years old.
Methodology:
Urinary organic acids are measured via GCMS, LC/MS/MS and alkaline picrate. Reference ranges are age and gender specific and are based on a questionnaire-qualified healthy cohort. Testing is not performed in patients under 2 years old.
Downloadable research
Noninvasive urinary organic acids test to assess biochemical and nutritional individuality in autistic children Research:
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- Broquist HP, Luhby AL. Detection and isolation of formiminoglutamic acid from urine in folic acid deficiency in humans. Proc Soc Exp Biol Med. 1959;100(2):349-354. https://journals.sagepub.com/doi/abs/10.3181/00379727-100-24623
- Sun A-l, Ni Y-h, Li X-b, et al. Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes. J Diabetes Res. 2014;2014. https://www.hindawi.com/journals/jdr/2014/921616/
- Kwok T, Cheng G, Lai W, Poon P, Woo J, Pang C. Use of fasting urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older persons. Nutrition. 2004;20(9):764-768.https://www.ncbi.nlm.nih.gov/pubmed/15325684
- Brown R, Thornton MJ, Price J. The effect of vitamin supplementation on the urinary excretion of tryptophan metabolites by pregnant women. J Clin Invest. 1961;40(4):617-623. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC290765/
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- Mitochondrial Medicine Society's Committee on D, Haas RH, Parikh S, et al. The in-depth evaluation of suspected mitochondrial disease. Mol Genet Metab. 2008;94(1):16-37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810849/
- Dimmock DP, Lawlor MW. Presentation and Diagnostic Evaluation of Mitochondrial Disease. Pediatr Clin North Am. 2017;64(1):161-171. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130109/
- Wu H, Jiang K, Gu G, Wu Y, Yu S. [The relationship of occupational stress and the level of some hormone metabolites in urine]. Chinese J Indust Hyg Occup Dis. 2014;32(2):83-86. https://www.ncbi.nlm.nih.gov/pubmed/24630003
- Jeon SW, Kim Y-K. Inflammation-induced depression: Its pathophysiology and therapeutic implications. J Neuroimmunol. 2017;313:92-98. https://www.ncbi.nlm.nih.gov/pubmed/29153615
- Hryhorczuk LM, Novak EA, Gershon S. Gut flora and urinary phenylacetic acid. Science. 1984;226(4677):996. https://science.sciencemag.org/content/226/4677/996.1
- Mora Brugues J, Gonzalez Sastre F. Influence of intestinal flora on the elimination of phenylacetic acid in urine. Clinical Chem. 1986;32(1 Pt 1):223. ttps://academic.oup.com/clinchem/article-abstract/32/1/223/5652268?redirectedFrom=fulltexth
- Del Rio D, Stalmach A, Calani L, Crozier A. Bioavailability of Coffee Chlorogenic Acids and Green Tea Flavan-3-ols. Nutrients. 2010;2(8):820. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257704/
- Pieczenik SR, Neustadt J. Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Path. 2007;83(1):84-92. https://www.ncbi.nlm.nih.gov/pubmed/17239370
- Caito SW, Aschner M. Mitochondrial Redox Dysfunction and Environmental Exposures. Antioxid Redox Signal. 2015;23(6):578-595. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544749/
- Depeint F, Bruce WR, Shangari N, Mehta R, O'Brien PJ. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact. 2006;163(1-2):94-112. https://www.ncbi.nlm.nih.gov/pubmed/16765926"
- Wojtczak L, Slyshenkov VS. Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals--the role of glutathione. BioFactors. 2003;17(1-4):61-73. https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.5520170107
- Tsoukalas D, Alegakis A, Fragkiadaki P, et al. Application of metabolomics: Focus on the quantification of organic acids in healthy adults. Int J Mol Med. 2017;40(1):112-120. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466383/
- Astarita G, Langridge J. An emerging role for metabolomics in nutrition science. J Nutrigenet Nutrigenom. 2013;6(4-5):181-200. https://www.karger.com/Article/FullText/354403"
- Anderson NM, Mucka P, Kern JG, Feng H. The emerging role and targetability of the TCA cycle in cancer metabolism. Protein Cell. 2017. https://link.springer.com/article/10.1007/s13238-017-0451-1
- Cardaci S, Ciriolo MR. TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State. Int J Cell Biol. 2012;2012:161837. https://www.hindawi.com/journals/ijcb/2012/161837/
- . Rojczyk-Golebiewska E, Kucharzewski M. Influence of chosen metals on the citric acid cycle. Pol Merkur Lekarski. 2013;34(201):175-178. https://www.ncbi.nlm.nih.gov/pubmed/23700830
- Strydom CRC. The effect of selected metals on the central metabolic pathways in biology: A review. Water SA. 2006. https://www.ajol.info/index.php/wsa/article/view/5155
- Nicolson GL. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Alt Therap Health Med. 2014;20 Suppl 1:18-25. http://www.alternative-therapies.com/index.cfm/fuseaction/Content.Main/id/72/E-pubAheadofPrint
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