Indications

• Drug effect

• Inherited enzyme deficit

• Nutrient deficiency

• Toxic build-up

Overview

The Organix Basic test provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions to help maximize patient responses and lead to improved patient outcomes.

Organic acids are metabolic intermediates produced in pathways of central energy production, detoxification, neurotransmitter breakdown, and intestinal microbial activity. Accumulation of specific organic acids in urine often signals a metabolic inhibition or block. An organic acids urine test helps reveal activity and changes at the metabolic level, helping practitioners discover hidden issues and pinpoint where therapeutic focus is needed.

The LC/MS-MS test method - which is also used to screen newborns for metabolic disorders - requires very little sample preparation and processing. This technology provides more stability, accuracy, and sensitivity in measuring organic acids at low levels for optimum test results.

Only a single overnight urine collection is required, which is easy for patients, leading to increased patient compliance.

Practical

Specimen requirements:

 Overnight urine, 12 ml, frozen

Average processing time:

17 ±6 days

Available add-on:

 Neopterin/Biopterin

Research

• Haas R, Parikh S, Falk M et al. The in-depth evaluation of suspected mitochondrial disease. Molecular Genetics and Metabolism. 2008;94(1):16-37.

• Jones P, Bennett M. Urine Organic Acid Analysis for Inherited Metabolic Disease Using Gas Chromatography-Mass Spectrometry. Methods in Molecular Biology. 2009:423-431.

• Kaluzna-Czaplinska J. Noninvasive urinary organic acids test to assess biochemical and nutritional individuality in autistic children. Clinical Biochemistry. 2011;44(8-9):686-691.

• Poplawski N, Harrison J, Norton W, Wiltshire E, Fletcher J. Urine amino and organic acids analysis in developmental delay or intellectual disability. Journal of Paediatrics and Child Health. 2002;38(5):475-480.

• Terán-García M, Ibarra I, Velázquez A. Urinary Organic Acids in Infant Malnutrition. Pediatric Research. 1998;44(3):386-391.