Indications

Indications for Candida

 Frequent use of:

• Antibiotics

• Oral contraceptives

• Refined carbohydrates

• Steroid medication

• Sugars

• Yeast-containing foods

Indications for Gliadin

This test requires a blood draw, so please ensure you can refer to a phlebotomist in the clients area before you order this test.

(Nordic Laboratories accepts no cost or claims related to any phlebotomy services in the event of sample rejection or failure for any reason. By ordering this, or any test requiring phlebotomy services, you accept any inherent risk and any associated costs.)

Overview

This test combines a 115 food IgG antibodies test, a candida test, and an anti-gliadin antibody test, to detect food allergies, precipitating antibodies to the fungus candida, and gluten sensitivity, respectively.

Overview for IgG 115

The majority of adverse immune reactions to foods classified as type II, III, or IV with delayed system onset, are mediated by IgG and are termed food sensitivities. It has been estimated that 90% of immune reactions to foods are non-IgE or delayed symptom onset food allergies. A single blood test can identify patient’s food sensitivities. Recommended treatments for food sensitivities is elimination of reactive foods from the diet for a period of 3 to 4 months followed by reintroduction and rotation. This test, tests for 115 foods.

Overview for Candida

A form of Candidiasis has emerged which manifests symptoms that are often systemic and cause considerable discomfort. It usually originates as an overgrowth of the fungal form of Candida occurring in the lower gastrointestinal tract.

 This test comprises of two tests designed to assist physicians in diagnosing Polysystemic Chronic Candidiasis (P.C.C.) The procedures are:

• The ELISA test offers high sensitivity and specificity in detecting early stage P.C.C. thus allowing prompt initiation of therapy.

• The Immunodiffusion test confirms late stage P.C.C. when antibody levels have risen significantly. Both tests are run on each patient sample.

Overview for Gliadin 

Over 100 chronic conditions, including celiac disease, have been associated with increased levels of Anti-Gliadin antibody (gliadin is the protein component of gluten). Since the 1970’s, gluten-free diets have shown to be a reliable treatment in allowing celiac patients to return to “normalcy”.

Recent research has shown the detection of Anti-Gliadin IgG and IgA to be an indicator of gliadin involvement in the medical condition. The test detects both IgG and IgA to gliadin by the ELISA method. This test is a very effective screening test for gliadin and is a good method for monitoring patients’ adherence to a gluten-free diet.

Practical

Specimen requirements:

Serum. Blood drawn.

This test requires a blood draw, so please ensure you can refer to a phlebotomist in the clients area before you order this test.

(Nordic Laboratories accepts no cost or claims related to any phlebotomy services in the event of sample rejection or failure for any reason. By ordering this, or any test requiring phlebotomy services, you accept any inherent risk and any associated costs.)

Average processing time:

17 ±9 days

Research related to IgG 115

• Barnes RMR Harvey MM Blears J et al, IgG Subclass of Human Serum Antibodies Reactive with Dietary Proteins, Int Archs Allergy appl. Immun, 1986.

• Cohen GA Hartman F Hamburger RN et al, Severe Anemia and chronic Bronchitis associated with a Markedly Elevated Specific IgG to Cow’s Milk Protein, Annals of Allergy, July 1985.

• Haddad, Vetter, Friedman, Samz, Brunner, Detection and kinetics of antigen-specific IgE and IgG immune complexes in food allergy, Annal of Allergy, August 1993.

• Kemeny RD Urbanek R Amlot PL et al, Sub-class of IgG in allergic disease, I IgG subclass antibodies in immediate and non-immediate food allergy, Clinical Allergy, 1986.

• Morgan JE, Daul CB, Lehrer SB, The relationships among shrimp-specific IgG subclass antibodies and immediate adverse reactions to shrimp challenge, J Allergy Clin Immunol, September 1990.

• Niggemann, B. et al, Outcome of double-blind, placebo controlled food challenge tests in 107 children with atopic dermatitis, Clin Exp Allergy, January 1999.

• Rafei A, Peters S, Harris N, and Bellani J, Food allergy and food-specific IgG measurement, Annals of Allergy,

February 1989.

Research related to Candida

• Abu-Elteen KH. The influence of dietary carbohydrates on in vitro adherence of four Candida species to human buccal epithelial cells. Microb Ecol Health Dis 2005; 17: 156-62.

• Jarvis WR. Epidemiology of Nosocomial Fungal Infections, with Emphasis on Candida Species. Clinical Infectious Diseases. 1995;20(6):1526-1530.

• Kennedy, M. J. and Volz, P.A., Effect of various antibiotics on gastrointestinal colonization and dissemination by Candida albicans, Sabouraudia, 23, 265–274, 1985.

• Lehmann PF, Reiss E. Comparison by Elisa of serum anti-Candida albicans mannan IgG levels of a normal population and in diseased patients. Mycopathologia. 1980;70(2):89-93.

• Montagna MT, Caggiano G, Borghi E, Morace G. The Role of the Laboratory in the Diagnosis of Invasive Candidiasis. Drugs. 2009;69(Supplement 1):59-63.

• Pires MFC, Corra B, Gambale W, Paula CR. Experimental model of Candida albicans (serotypes A and B) adherence in vitro. Braz J Microbiol 2001; 32: 163-9.

• Pizzo G, Giuliana G, Milici ME, Giangreco R. Effect of dietary carbohydrates on the epithelial adhesion of Candida albicans, Candida tropicalis, and Candida krusei. New Microbiol 2000; 23: 63-71.

• Seelig MS. The role of antibiotics in the pathogenesis of Candida infections. The American Journal of Medicine. 1966;40(6):887-917.

• Seligmann, E., Virulence enhancement of Candida albicans by antibiotics and cortisone. Proc. Soc. Exp. Biol. Med., 1953. 83: p. 778–781. 68.

• Vojdani A, Rahimian P, Kalhor H, Mordechai E. Immunological cross reactivity between Candida albicans and human tissue. J Clin Lab Immunol. 1996;48(1):1-15.

Research related to Gliadin

• Chinnery PF et al, CSF antigliadin antibodies and the Ramsay Hunt syndrome, Neurology, October 1987.