DNA Histamine (HNMT & DAO)

Overview

DNA Histamine evaluates genetic variation in two key enzymes responsible for histamine breakdown: diamine oxidase (DAO), which primarily acts in the gut to metabolise dietary histamine, and histamine N-methyltransferase (HNMT), which helps regulate intracellular histamine levels in tissues such as the central nervous system. Histamine functions as an important signalling molecule across immune, neurological and gastrointestinal processes.

Differences in DAO and HNMT activity may influence how histamine accumulates or is cleared following food intake, environmental exposures or physiological stress. Altered histamine handling has been associated with symptom patterns including headaches, skin reactivity, digestive disturbances and selective medication intolerance amongst others.

Results are interpreted alongside dietary history, symptom patterns, medication use and other functional assessments. Reviewing genetic findings within this broader clinical context can support more personalised discussion around food strategies, environmental triggers and symptom management approaches.