Functional Tests

H. Pylori (stand alone)

Overview

The H. pylori (stand alone) test uses quantitative PCR technology to detect Helicobacter pylori DNA in a stool sample, along with associated virulence factors and selected antibiotic resistance genes. This molecular approach offers high analytical sensitivity and allows practitioners to review both the presence of H. pylori and any additional genetic markers linked with strains of interest.

Clinically, this assessment may be useful when exploring upper digestive symptoms such as reflux, nausea, bloating, abdominal discomfort or appetite changes. The inclusion of virulence factors provides further context when symptoms are persistent or more severe, and resistance markers can help inform discussions about how best to manage cases that have not responded as expected. It is also relevant as a follow up option after a GI MAP result that has previously shown H. pylori.

Practitioners typically interpret these findings alongside symptom history, dietary patterns, previous test results and any relevant clinical decisions already made. The H. pylori (stand alone) test can offer clear, focused information when H. pylori status is the primary question and may support broader digestive health assessments.

Indications


  • Upper digestive symptoms: persistent bloating, nausea, reflux or discomfort after meals.
  • Ongoing stomach pain: burning, cramping or tenderness in the upper abdomen.
  • Appetite changes: reduced appetite or early fullness.
  • Unexplained fatigue: tiredness that may coincide with digestive discomfort.
  • Nausea or queasiness: symptoms that fluctuate around eating patterns.
  • Clients with a history of H. pylori: monitoring following previous findings or treatment.
  • Practitioners exploring causes of chronic digestive symptoms: when routine investigations have not clarified the picture.
  • Recurrent dyspepsia: ongoing indigestion or post meal discomfort.
  • Family or household exposure concerns: when close contacts have a known H. pylori infection.
  • Follow up assessment: as a standalone retest after a GI MAP result showing H. pylori.

Practical

Specimen

Stool sample 

Container

  • 1x orange-capped stool vial

Patient preparation

  • Please refrain from taking aspirin for two days prior to collecting your sample.
  • Never discontinue prescription medication without first consulting your physician.


Note: This test can be ordered as a stand-alone. H. pylori and virulence factors are included in the GI-MAP and GI-MAP plus Zonulin tests.

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Research