Functional Tests

Human Herpes Virus (HHV) 6 - EliSpot

Overview

The Human Herpes Virus (HHV)-6 EliSpot test measures T-cell activity specific to HHV-6 using an enzyme-linked immunospot assay, one of the most sensitive methods for detecting cellular immune responses. This technique identifies cytokine-producing T cells, offering insight into immune engagement even when antibody responses (IgG/IgM) alone do not provide a full picture. The test requires three ACD/CPDA blood tubes for accurate analysis.

Practitioners may consider this assessment when clients present with prolonged or fluctuating symptoms such as fatigue, cognitive changes, temperature variations or sleep disturbances in the context of suspected viral involvement. Because HHV-6 can remain latent and reactivation may not always trigger strong antibody responses, cellular testing can add clarity when humoral markers appear inconsistent with the clinical history.

Results are typically interpreted alongside antibody testing, symptom timelines, lifestyle factors and broader immune-related assessments. This combination may help practitioners explore how cellular responses relate to overall immune balance and the client’s wider health picture.

Indications


  • Persistent fatigue: ongoing tiredness where viral involvement is being explored.
  • Temperature changes: intermittent low-grade fevers or warm spells.
  • Neurological concerns: headaches, reduced concentration or cognitive fluctuations.
  • Mood changes: irritability, anxiety or emotional instability linked with prolonged unwellness.
  • Musculoskeletal discomfort: muscle aches or generalised body tension.
  • Sleep disturbances: difficulty staying asleep or non-refreshing sleep.
  • Immune profiling: assessing T-cell responses alongside IgG/IgM when antibody patterns are unclear.
  • Viral reactivation concerns: fluctuating symptoms possibly associated with latent viral activity.

Practical

3 x ACD/CPDA tube

This sample requires a blood draw

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Research