Functional Tests

HuMap™

Overview

Much like a human fingerprint, metabolism is inherently unique to everyone. Understanding how the major hormones of the body are metabolized as well as the activity of the enzymes responsible for metabolism is a rare glimpse into a patient’s health. 

HuMap™ is non-invasive test that requires only 4 or 5 separate urine collections. Because the breakdown of hormones relies so heavily on processes within the liver, this test can also elucidate areas of interest as it pertains to conjugation of each metabolite. Additionally, testing urinary hormone metabolites can contribute to further understanding of endogenous hormone secretion, supplemental hormone utilization, enzyme activity, oxidative stress, and insight into how your body metabolizes hormones.

Analytes

  • 11-Deoxycortisol
  • 11-hydroxy-Androsterone
  • 11-hydroxy-Etiocholanolone
  • 17-Hydroxyprogesterone
  • 21-Hydroxyprogesterone
  • 5a-Androstanediol
  • 5a-Dihydrotestosterone
  • 5a-Pregnanediol
  • 5a-Tetrahydrocorticosterone
  • 5a-Tetrahydrocortisol
  • 5b-Androstanediol
  • 5b-Pregnanediol
  • 5b-Tetrahydrocorticosterone
  • 5b-Tetrahydrocortisol
  • 5-Pregnanetriol
  • 8-hydroxy-2-deoxyguanosine
  • Allopregnanolone
  • Androstenedione
  • Androsterone
  • Corticosterone
  • Cortisol Bedtime
  • Cortisol Dinnertime
  • Cortisol Waking +2 hours
  • Cortisol Waking
  • Cortisol/day
  • Cortisone Bedtime
  • Cortisone Dinnertime
  • Cortisone Waking +2 hours
  • Cortisone Waking
  • Cortisone/day
  • Creatinine/day
  • Dehydroepiandrosterone Sulfate
  • Dehydroepiandrosterone
  • EPI-Testosterone
  • Etiocholanolone
  • Progesterone
  • Testosterone
  • Tetrahydrocortisone
  • Tetrahydrodehydrocorticosterone
  • Estrone (E1)
  • Estradiol (E2)
  • Estriol (E3)
  • 2-Hydroxyesterone (2-OH-E1)
  • 4-Hydroxysterone (4-OH-E1)
  • 16a-Hydroxyestrone (16-OH-E1)
  • 2-Methoxyestrone (2-M-E1)
  • 4-Methoxyestrone (4-M-E1)
  • 2-Hydroxyestradiol (2-OH-E2)
  • 4-Hydroxyestradiol (4-OH-E2)
  • 2-Methoxyestradiol (2-M-E2)
  • 4-Methoxyestradiol (4-M-E2)

Indications

The Hormone and Urinary Metabolites Assessment Profile (HuMapTM)

Provides a comprehensive overview of steroid hormones, their metabolites, and the efficiency of the enzymes that metabolize these hormones

HuMap is a comprehensive urinary metabolite profile designed to provide deep insight into the secretion and metabolism of unconjugated sex hormones and their metabolites, and the enzymes that fuel these conversions.

Indications

Female

  • Menopausal symptoms 
  • Breast Health 
  • Endometriosis 
  • PCOS 
  • PMS/PMDD


Male

  • Erectile dysfunction 
  • Prostate health 
  • Loss of muscle mass 
  • Breast health


General

  • Metabolic syndrome 
  • Thyroid pathologies 
  • Inflammation 
  • Oxidative Stress 
  • Fatigue/insomnia 
  • Libido 
  • Mood or cognitive concerns 
  • Family history of hormone-driven cancers 
  • HRT/BHRT utilization 
  • Weight gain


Practical

Specimen

Urine

Container

5 color-coded urine tubes

Patient preparation

  • 24 hours prior and during collection: avoid alcohol, caffeine, tobacco or nicotine-containing products and strenuous exercise.
  • Hormones may need to be discontinued for a period of time

Research