Functional Tests

OMX - Urine

Overview

Overview

Understanding an individual's metabolome, combined with their medical history and lifestyle, allows clinicians to establish a larger picture and provide support from the bottom up. Ideally, practitioners will use OMX to establish a baseline metabolic signature for healthy patients. The baseline could be used for future comparison if symptoms, disease, or illness occurs.

Analytes


Metabolic processing
  • Glucose
  • Pyruvic Acid
  • Lactic Acid
  • Alanine
  • Citric Acid
  • cis-Aconitic Acid
  • Isocitric Acid
  • alpha-Ketoglutaric acid
  • Succinic acid
  • Fumaric Acid
  • Malic Acid
  • Adipic Acid
  • Suberic Acid
  • Pimelic Acid
  • Hxanoylglycine
  • Suberylglycline
  • 3-Phenylpropionylglycine
  • Thylmalonic acid
  • 2-Methylsuccinic Acid
  • Beta-Hydroxybutyric Acid









Nutrition

  • Branched chain Alpha-Keto organic Acids
  • Aplha- Ketoglutaric Acid
  • Pyruvic Acid
  • Methylmalonic Acid
  • Formiminoglutamic Acid
  • Pyridoxic Acid
  • Xanthurenic Acid
  • Beta-Hydroxyisovaleric Acid
  • Quercetin
  • Tartaric Acid
  • 1-Methylhistidine
  • Carnosine
  • Anserine
  • Fructose













Amino acid and Protein Metabolism

  • Phenylalanine
  • Phenylacetic Acid
  • Tyrosine
  • Homovanillic Acid
  • Vannilylmandelic Acid
  • 4-Hydroxyphenylpyruvic Acid
  • Homogentisic Acid
  • Total branched chain amino acids
  • Valine
  • alpha-Ketoisovaleric acid
  • Isoleucine/Allo-Isoleucine
  • alphat-keto-beta-methyivaleric Acid
  • Leucine
  • alpha-Ketoisocaproic Acid
  • Tryptophan
  • 5-Hydroxyindoleacetic Acid
  • Kynurenine
  • KT Radio
  • Hydroxykynurenine
  • Xanthurenic Acid
  • Anthranilic Acid
  • Picolinic Acid
  • Kynurenic Acid
  • Quinolinic Acid
  • Methionine
  • Homocystine
  • Cystathionine
  • Sulfocysteine
  • Taurine
  • Cystine
  • alpha-Hydroxybutyric Acid
  • Pyroglutamic Acid
  • Histidine
  • 3-Methylhistidine
  • Beta-Alanine
  • Threonine
  • Glycine
  • Serine
  • Sarcosine
  • Ethanolamine
  • Phosphoethanolamine
  • Lysine
  • alpha-Aminoadipic Acid
  • Glutaric Acid
  • Glutamine
  • Glutamic Acid
  • Glutamine/Gluramate Ratio
  • Asparagine
  • Aspartic Acid
  • Proline
  • Hydroxyproline
  • Glycylproline
Toxic Impacts


8-Hydroxy-2'-deoxyguanosine
2-Methylhippuric Acid
Mandelic Acid
Benzoylform
Glucaric Acid
Arginine
Citrulline
Ornithine
Homocitrulline
Arginosuccinic Acid
Orotic Acid
Microalbumin
Phospate
Creatinine
Oxalic Acid

Stress and Mood


Amino butiric Acid
Homovanillic Acid
Vannylmandelic Acid
5-Hydroxyindolacetic Acid
Cortisol

Microbial Metabolites

4-Hydroxyphenylacetic Acid
Indolacetic Acid
3,4 Dihydrocinnamic Acid
3,5-Dihydroxybenzoic Acid
4-Hydroxybenzoic Acid
Benzoic Acid
Hippuric Acid
Equol
Arabinitol



Methodology

LC-MS/MS


Indications

The OMX™ Organic Metabolomics test evaluates urine metabolites—including organic acids, amino acids, and other key compounds—to assist practitioners in unraveling their patient’s metabolic pathways, revealing their unique Metabolic Signature.

OMX™ metabolomic testing goes beyond traditional organic acid testing. OMX characterizes metabolic phenotypes by presenting analytes in pathway categories to more easily identify metabolomic deviations that can underlie—and even precede—disease

Indications

  • Mood Disorders
  • Mitochondrial Dysfunction
  • Fatigue
  • Chronic Stress
  • Inflammation
  • Depression, 
  • Cardiovascular disease,
  • Neurocognitive decline
  • Diabetes

Practical

Specimen

Urine

Please be aware that urine sampling is representative of recent dietary intake and metabolism of amino acids, it is more variable than in plasma. It is useful for controlled diets or to assess for efficacy of recent dietary changes (typically last 24/48 hours). Amino acid levels in urine can be influenced by abnormal kidney function and is ideal for children and adults as it is conveniently collected at home.

Container

Yellow capped Cup

Patient preparation

  • Avoid consuming fruits, jams, and jellies for 48 hours prior to collection


Research

  1.  U.S. Department of Health and Human Services. (2016, March 9). Metabolomics Overview. National Institutes of Health. Retrieved November 23, 2021
  2. Hood, L. as cited in Miller, I.J., Peters, S.R., Overmyer, K.A. et al. Real-time health monitoring through urine metabolomics. npj Digit. Med. 2, 109 (2019). 
  3. Beger RD, Dunn W, Schmidt MA, et al. Metabolomics enables precision medicine: "A White Paper, Community Perspective". Metabolomics. 2016;12(10):149.